Trachoma, caused by repeated eye infection with the bacterium Chlamydia trachomatis (Ct), which can progress to the in-turning of the eyelids resulting in at least one eyelash touching the globe of the eye, is the leading infectious cause of blindness worldwide. NMIMR in close collaboration with Ghana Health Service and Sight Savers, Ghana has worked towards implementing trachoma surveillance strategy, which includes community screening for signs of trachoma endemic districts. In 2015, a district level population-based survey to validate elimination of trachoma as a public health problem was conducted. This provided an opportunity to review any ‘hotspots’ of infection identified during the surveillance stage as well as identify whether the country has attained the elimination criteria. Though some levels of infections were identified, it was concluded that Ghana has successfully eliminated trachoma as a public health problem. Based on this and other previously collected data, a dossier was prepared and submitted to WHO for validation. Ghana was subsequently validated as having eliminated trachoma as a public health problem in 2018. In addition, the survey showed that the surveillance system of the Ghana Heath service could be strengthened to assess on-going transmission and the implications for re-emergence of Trachoma.