Follow us :

Clinical Pathology

Clinical Pathology
To conduct high-ended research that contributes to intervention strategies and safeguards public health in Ghana
  • Conduct research into communicable and non-communicable diseases
  • Encourage a high level of integrity and technical excellence in research and the provision of laboratory services for the benefit of Ghanaians
  • Create an exceptional research training and mentoring environment for staff, students and postdoctoral fellows

Disease Research Areas

Key Research Findings

Key Facilities & Labs

Key Services

Key Research Projects
Gallery
Research Scientists
Prof. Dziedzom de-Souza
HOD, Associate Professor
DR. KWABENA O. DANQUAH
Research Fellow
Dr. Justice Kumi, Chief Research Assistant
Research Fellow
Research Staff
Abigail Aning, Principal Research Assistant
Principal Research Assistant
Elisha Larbi Nketia
Principal Research Assistant
Louisa Acquah, Research Assistant Sickle Cell Project
Research Assistant
Janet Abena Ampofo
Technologist
Administrative Assistant
Ms. Angela Asantewaa-Principal Administrative Assistant
Principal Administrative Assistant
Key Publications

Plant Medicine Research

Anticancer

  1. J.K. Abankwa, E. Dotse, R. Appiah-Opong, A.K. Nyarko (2020). Antioxidant and anti-prostate cancer activities of Moringa oleifera, Phyllanthus amarus and Carica papaya. Health Sciences Investigations Journal. 1(1):24-30.
  2. P. Amoateng, E.O. Bekoe, S.K. Amponsah, R. Appiah-Opong, D. Osei-safo, B.B. N’guessan, M.V.N.L. Chaitanya, R. Rajeshkumar, S.P. Dhanabal. (2020) Antioxidant and anti-proliferative effects of an ethyl acetate fraction of the hydro-ethanolic extract of Synedrella nodiflora (L) gaertn. International Journal of Pharmacy and Pharmaceutical Sciences, 12(11):136-143
  3. B.B. N’guessan, A.D. Asiamah, N.K. Arthur, S. Frimpong-Manso, P. Amoateng, S.K. Amponsah, K.E. Kukuia, J.A. Sarkodie, K.F-M. Opuni, I.K. Asiedu-Gyekye, R. Appiah-Opong. (2021) Ethanolic extract of Nymphaea lotus L. (Nymphaeaceae) leaves exhibits in vitro antioxidant, in vivo anti-inflammatory and cytotoxic activities on Jurkat and MCF-7 cancer cell lines. BMC Complementary Medicine and Therapies (2021) 21:22 doi.org/10.1186/s12906-020-03195-w

 

Antimalarial

  1. Kwansa-Bentum, K. Agyeman, J. Larbi-Akor, C. Anyigba, R. Appiah-Opong. (2019). In vitro assessment of antiplasmodial activity and cytotoxicity of Polyalthia longifolia leaf extracts on Plasmodium falciparum strain NF54. Malaria Research Treatment doi.org/10.1155/2019/6976298
  2. I. Dadzie, S.A. Avorgbedo, R. Appiah-Opong, O. Cudjoe. (2020) Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures. International Journal of Microbiology, Doi.org/10.1155/2020/8645691
  3. C.J. Ikem, R. Appiah-Opong, A.N. Oli, M.C. Ugwu, P. Amoateng, K. Agyemang, D.C. Nwobodo, C.O. Esimone. (2020). In vitro and in vivo antiplasmodial assays of selected Nigerian commercial herbal formulations. Journal of Herbmed Pharmacology, 9(4):374-381.
  4. E.K. Kumatia, F. Ayertey, R. Appiah-Opong, P. Bolah, E. Ehun, J. Dabo. (2021) Antrocaryon micraster (A. Chev. And Guillaumin) stem bark extract demonstrated anti-malaria action and normalized hematological indices in Plasmodium berghei infected mice in the Rane’s test. Journal of Ethnopharmacology, doi.org/10.1016/j.jep.2020.113427
  5. E.K. Kumatia, F. Ayertey, R Appiah-Opong, G.K. Bagyour, K.O. Asare, V.C. Mbatcho, J. Dabo. (2021). Intervention of standardized ethanol leaf extract of Annickia polycarpa, (DC.) Setten and Maas ex I.M. Turner. (Annonaceae), in Plasmodium berghei infected mice produced anti-malaria action and normalized gross hematological indices. Journal of Ethnopharmacology, doi.org/10.1016/j.jep.2020.113449
  6. J.N. Amissah, F.E. Alorvor, B.A. Okorley, C.M. Asare, D. Osei-Safo, R. Appiah-Opong, I. Addae-Mensah. (2022). Mineral fertilization influences the growth, Cryptolepine yield, and bioefficacy of Cryptolepis sanguinolenta (Lindl.) Schlt. Plants, 11:122. https:// doi.org/10.3390/plants11010122
  7. R. Appiah-Opong, K. Agyemang, E. Dotse, P. Atchoglo, K. Baffour-Awuah Owusu, A. Aning, M. Sakyiamah, R. Adegle, F. Ayertey, A. Ampomah Appiah, A. K. Nyarko. (2022). Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants. Journal of Evidence-Based Integrative Medicine, 27: 1-8. doi: 10.1177/2515690X211073709

 

Anti-leishmanial

  1. R.T. Yamthe, T.J. Philips, D. Osei-Safo, P.T. Djouonzo, O. Agyapong, E. Dotse, P.V.T. Fokou, S.K. Kwofie, F.F. Boyom, A.K. Nyarko, R. Appiah-Opong, M.D. Wilson. (2020). Antileishmanial effects of Sargassum vulgare products and prediction of trypanothione reductase inhibition by fucosterol. Future Drug Discovery, doi.org/10.4155/fdd-2020-0002
  2. K. Kowa, L.R.Y. Tchokouaha, J.N. Nyemb, H.K. Wabo, A.T. Tchinda, R. Appiah-Opong, G.A. Agbor, P. Tane, M. Frederich. (2020). Antipromastigote and cytotoxic activities of some chemical constituents of Hypericum lanceolatum Lam. (Guttifereae). Journal of Applied Pharmaceutical Science, 10(1):026-032.

 

Anti-schistosomal, anti-onchocercal and anti-trypanosomal

  1. E.B. Twumasi, P.I. Akazue, K. Kyeremeh, T.M. Gwira, J. Keiser, F. Cho-NgwaI, A. Flint, B. Anibea, E.Y. Bonsu,

R.K. Amewu, L.E. Amoah, R. Appiah-Opong, D. Osei-Safo. (2020). Anti-schistosomal, anti-onchocercal and anti-trypanosomal potentials of some Ghanaian traditional medicines and their constituents. PLOS Neglected Tropical Diseases, doi.org/10.1371/journal.pntd.0008919

 

Drug interactions

  1. K. Amponsah, B.B. N’guessan, M. Akandawen, A. Aning, S.Y. Agboli, E.A. Danso, K. F-M. Opuni, I.J. Asiedu-Gyekye, R. Appiah-Opong. (2020) Effect of Cellgevity supplement on selected rat liver cytochrome P450 enzyme activity and pharmacokinetic parameters of carbamazepine. Evidence-Based Complementary and Alternative Medicine doi.org/10.1155/2020/7956493

 

Other Publications

  1. S. Achampong, R. Appiah-Opong, A. Ocloo. (2019) Effects of Aqueous Extracts of Taraxacum officinale, Morinda citrifolia, Milletia thonningii and Noni on Mitochondrial function. Journal of Biological Sciences, 19 (6):381-390.
  2. Ayertey, E. Ofori-Attah, S. Antwi, M. Amoa-Bosompem, G. Djameh, N.L. Lartey, M. Ohashi, K.A. Kusi, A.A. Appiah, R. Appiah-Opong, L.K. Okine. (2020) Anti-inflammatory activity and mechanism of action of hydroethanolic leaf extract of Morinda lucida Benth. Journal of Traditional and Complementary Medicine, 11(3):249-258. doi.org/10.1016/j.jtcme.2020.07.001
  3. R. Appiah-Opong. (2020) The coronavirus (COVID) pandemic. Health Sciences Investigations Journal. 1(1):3-4.

 

Environmental Toxins – Mycotoxins and Heavy metals

  1. Kumi, KA.A-O. Agyei-Heneku, M. Ofosuhene. (2019) Levels of aflatoxins and fumonisins in poultry feed from Ghana. Online Journal of Animal Feed Research, 9(6):241-246.
  2. Ofori-Attah, A. Aning, M. Ofosuhene, J. Kumi, R. Appiah-Opong. (2021). Determination of aflatoxin levels in bokina beverage. Ghana Medical Journal, 55(4): 292-297. doi: http://dx.doi.org/10.4314/gmj.v55i4.10
  3. Appiah‑Opong, A. Ofori, M. Ofosuhene, E. Ofori‑Attah, F.K.E. Nunoo, I. Tuffour,· C. Gordon, D.K. Arhinful, A.K. Nyarko, B.Y. Fosu‑Mensah. (2021). Heavy metals concentration and pollution index (HPI) in drinking water along the southwest coast of Ghana. Applied Water Science, doi.org/10.1007/s13201-021-01386-5 
Internal Collaborator(s)
External Collaborator(s)
Funder(s)