The Noguchi Memorial Institute for Medical Research Scientific and Technical Committee (NMIMR-STC) was established in 1982 with the mandate to examine the objectives, relevance, scientific quality, and budgets of all proposed research projects and also review the progress of their execution. An ancillary responsibility of the committee was to serve as a conference committee of the Institute. 

The NMIMR-STC conducts the scientific evaluation of all research proposals and amendments proposed by NMIMR staff before onward submission to the Institutional Review Board (IRB) for ethical considerations and approvals, and study initiation. The STC reviews encompass an assessment of the scientific rationale and merit of a proposed study in addition to the protocol design, safety considerations and biostatistical analysis to determine if it is of high quality and if appropriate designs are being used to address the study question(s). It also reviews informed consent documents to assess their scientific accuracy and ensure that participants are informed of risks, side effects, and any alternative treatments. 

The STC may invite scientists outside the Institute who have the expertise as co-opted reviewers, which is done by the coordinator in consultation with the chairperson. The co-opted reviewers have the option of either participating physically in the deliberations or sending in written reports.