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Neglected Tropical Diseases (Epidemiology, molecular biology, Drug discovery)

Neglected Tropical Diseases (Epidemiology, molecular biology, Drug discovery)

Project Lead(s)
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Project Background 

Neglected tropical diseases (NTDs) are a diverse group infection of tropical and subtropical regions, especially among the poor, caused by a variety of pathogens such as viruses, bacteria, protozoa and parasitic worms (helminths). Approved treatment drugs for NTDs are faced with several limitations, such as emergence of resistant pathogens, high costs and toxicity arising from long periods of high dose treatments, which warrant the search for alternative drugs, ideally among natural compounds

Objectives/Research Areas 
  1. Assessing the efficacy of the 3 quinone compounds (22, 31 and 32) from the Ōmura natural compound library against Schistosoma mansoni worms in vitro and in experimental mice models.
  2. Elucidating the mechanisms of action of the compounds in mansoni schistosomula.
Key Publications  
  1. Kofi Dadzie Kwofie, Kai Sato, Chizu Sanjoba, Akina Hino, Rieko Shimogawara, Michael Amoa-Bosompem, Irene Ayi, Daniel A. Boakye, Abraham K. Anang, Kyung-Soo Chang, Mitsuko Ohashi, Hye-Sook Kim, Nobuo Ohta, Yoshitsugu Matsumoto, Shiroh Iwanaga. Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against donovani complex. PLOS-NTD 13 (3): e0007235 (2019)

 

  1. Ohashi M, Amoa‐Bosompem M, Kwofie KD Jefferey Agyapong, Richard Adegle, Maxwell Mamfe Sakyiamah, Frederick Ayertey, Kofi Baffuor‐Awuah Owusu, Isaac Tuffour,  Philip Atchoglo, Nguyen Huu Tung, Takuhiro Uto, Frederick Aboagye, Alfred Ampomah Appiah, Regina Appiah-Opong, Alexander K. Nyarko, William Kofi Anyan, Irene Ayi,  Daniel Adjei Boakye, Kwadwo Ansah Koram,  Dominic Edoh,  Shoji Yamaoka, Yukihiro Shoyama, Nobuo Ohta. In vitro antiprotozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania, and Plasmodium Phytotherapy Research. 32:1617–1630. (2018)

 

  1. Faustus Akankperiwen Azerigyik, Michael Amoa-Bosompem, Thelma Tetteh, Frederick Ayertey, Ama Nyamekye Antwi, Kofi Baffour-Awuah Owusu, Kofi Kwofie Dadzie , Georgina Isabella Djameh, Mark Tetteh-Tsifoanya, Shiro Iwanaga, Alfred Ampomah Appiah, Tomoe Ohta, Takuhiro Uto, Yukihiro Shoyama, Nobuo Ohta, Theresa Manful Gwira, Mitsuko Ohashi. In vitro Mechanistic Assays of Tetracyclic Iridoid Compounds Isolated from Morinda lucida Benth in Leishmania European Journal of Medicinal Plants 25 (4):1-14 (2018)
  1. Kwofie KD, Tung NH, Suzuki-Ohashi M, Amoa-Bosompem M, Adegle R, Sakyiamah MM, Ayertey F, Owusu KB-A, Tuffour I, Atchoglo P, Frempong KK, Anyan WK, Uto T, Morinaga O, Yamashita T, Aboagye F, Appiah AA, Appiah-Opong R, Nyarko AK, Yamaguchi Y, Edoh D, Koram KA, Yamaoka S, Boakye DA, Ohta N, Shoyama Y, Ayi I. Anti-trypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth. Antimicrobial Agents and Chemotherapy 60 (6): 3283-3290 (2016)
  1. Michael Amoa-Bosompem, Mitsuko Ohashi, Mba-Tihssommah Mosore, Jeffrey Agyapong, Nguyen Huu Tung, Kofi D. Kwofie, Frederick Ayertey, Kofi Baffuor-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Georgina I. Djameh, Faustus A. Azerigyik, Senyo K. Botchie, William K. Anyan, Regina Appiah-Opong, Takuhiro Uto, Osamu Morinaga, Alfred. A. Appiah, Irene Ayi, Yukihiro Shoyama, Daniel A Boakye and Nobuo Ohta. In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth. Tropical Medicine and Health 44:25 (2016)
  1. Mitsuko Suzuki, Nguyen Huu Tung, Kofi D. Kwofie, Richard Adegle, Michael Amoa Bosompem, Maxwell Sakyiamah, Frederick Ayertey, Kofi Baffour-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Regina Appiah-Opong, Alexander K. Nyarko, Shoji Yamaoka, Yasuchika Yamaguchi, Dominic Edoh, Kwadwo Koram, Nobuo Ohta, Daniel A. Boakye, Irene Ayi, Yukihiro Shoyama. New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth. Bioorganic & Medicinal Chemistry Letters 25(15) (2015)
  1. Satoru Karasawa, Kenji Yoza, Nguyen Huu Tung, Takuhiro Uto, Osamu Morinaga, Mitsuko Suzuki, Kofi D. Kwofie, Michael Amoa-Bosompem, Daniel A. Boakye, Irene Ayi, Richard Adegle, Maxwell Sakyiamah, Frederick Ayertey, Frederic Aboagye, Alfred A. Appiah, Kofi B.-A. Owusu, Isaac Tuffour, Philip Atchoglo, Kwadwo K. Frempong, William K. Anyan, Regina Appiah Opong, Alexander K. Nyarko, Taizo Yamashita, Yasuchika Yamaguchi, Dominic Edoh, Kwadwo Koram, Shoji Yamaoka, Nobuo Ohta, Yukihiro Shoyama. Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated from Morinda lucida by X-ray analysis Tetrahedron Letters 56(52), 7158-7160 http://dx.doi.org/10.1016/j.tetlet.2015.11.031 (2015)
  1. Tung, N. H., Suzuki, M., Uto, T., Morinaga, O., Kwofie, K. D., Ammah, N., Koram, K. A.,  Aboagye, F.,  Edoh, D., Yamashita, T.,  Yamaguchi, Y.,  Setsu, T.,  Yamaoka, S.,  Ohta, N. and Shoyama, Y.  Anti-trypanosomal Activity of Diarylheptanoids Isolated from the Bark of Alnus japonica Steud. Am. J. Chin. Med. 42 (5) pp 1-16 (2014)
Team 
External Collaborator(s) 
Naotoshi Tsuji, Professor, Department of Parasitology and Tropical Medicine, Kitasato University School of Medicine, Japan.
Takeshi Hatta, Associate Professor, Department of Parasitology and Tropical Medicine, Kitasato University School of Medicine, Japan.
Funder(s) 
JSPS Asian-African Core-to-Core Program (JPJSCCB20200010). Co-investigator. The efficacy of Quinone compounds from Ōmura natural compound library against Schistosoma mansoni. (2020-2023