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Point of Care Diagnostic Tool Development

Point of Care Diagnostic Tool Development

Project Lead(s)
Director Dorothy Yeboah-Manu
Prof. Dorothy Yeboah-Manu
Professor
DR. ABLODEY
Prof. Anthony Ablordey
HOD, Associate Professor
Key Publications  
  1. Ablordey, A., Ahotor, E., Narh, C. A., King, S. A., Cruz, I., Ndung'u, J. M., & de Souza, D. K. (2021). Evaluation of different DNA extraction methods and loop-mediated isothermal amplification primers for the detection of Mycobacterium ulcerans in clinical specimens. BMC Infectious Diseases, 21(1), 598. doi:10.1186/s12879-021-06308-z
  2. Ablordey, A., Amissah, D. A., Aboagye, I. F., Hatano, B., Yamazaki, T., Sata, T., . . . Katano, H. (2012). Detection of Mycobacterium ulcerans by the loop mediated isothermal amplification method. PLoS Neglected Tropical Diseases, 6(4), e1590. doi:10.1371/journal.pntd.0001590
  3. Kotlowski, R., Martin, A., Ablordey, A., Chemlal, K., Fonteyne, P. A., & Portaels, F. (2004). One-tube cell lysis and DNA extraction procedure for PCR-based detection of Mycobacterium ulcerans in aquatic insects, molluscs and fish. Journal of Medical Microbiology, 53(Pt 9), 927-933. doi:10.1099/jmm.0.45593-0
  4. Njiru, Z. K., Yeboah-Manu, D., Stinear, T. P., & Fyfe, J. A. (2012). Rapid and sensitive detection of Mycobacterium ulcerans by use of a loop-mediated isothermal amplification test. Journal of Clinical Microbiology, 50(5), 1737-1741. doi:10.1128/JCM.06460-11
  5. Sakyi, S. A., Aboagye, S. Y., Otchere, I. D., Liao, A. M., Caltagirone, T. G., & Yeboah-Manu, D. (2016). RNA Aptamer That Specifically Binds to Mycolactone and Serves as a Diagnostic Tool for Diagnosis of Buruli Ulcer. PLoS Neglected Tropical Diseases, 10(10), e0004950. doi:10.1371/journal.pntd.0004950
  6. Wadagni, A., Frimpong, M., Phanzu, D. M., Ablordey, A., Kacou, E., Gbedevi, M., . . . Asiedu, K. (2015). Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography. PLoS Neglected Tropical Diseases, 9(11), e0004247. doi:10.1371/journal.pntd.0004247
Team 
External Collaborator(s) 
Prof. Gerd Pluschke,Swiss TPH
Dr. Janet Fyfe, VIDRL, Melbourne
Prof. Timothy Stinear, University of Melbourne
Dr. Ernestina Mensah Quinooh
Dr. Albert Paintstil, KBTH
Dr. Edwin Ampadu, NBUCP
Funder(s) 
Heidelberg University Hospital
Ghana Health Service
UBS Optimus Foundation
Kanton Basel-Stadt
Stop Buruli
VolkswagenStiftung