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Clinical Pathology

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Clinical Pathology
Vision Statement
To conduct high-ended research that contributes to intervention strategies and safeguards public health in Ghana
Mission Statement
  • Conduct research into communicable and non-communicable diseases
  • Encourage a high level of integrity and technical excellence in research and the provision of laboratory services for the benefit of Ghanaians
  • Create an exceptional research training and mentoring environment for staff, students and postdoctoral fellows

Disease Research Areas

  • Anticancer drug discovery
  • Antimalarial drug discovery
  • Anti-COVID-19 drug discovery
  • Pharmacokinetic drug interactions studies
  • Environmental toxicology (a) Mitigation of mycotoxin exposure (1) Investigations on heavy metal exposure in the environment

Key Research Findings

  • Plant extracts and compounds with various anticancer activities as drug candidates
  • Plant extracts and compounds with antimalarial activity as drug candidates
  • Herb-drug interactions potentials of some marketed antimalarial, anti-TB and anti-HIV herbal medicines
  • Exposure of humans and foods to aflatoxins and safety and efficacy of novasil clay in eliminating aflatoxin.
  • Heavy metal contamination in communities near the Jubilee oil drilling site in the Western region of Ghana

Key Facilities & Labs

  • UV/Vis Spectrophotometer
  • Atomic Absorption Spectrophotometer
  • High-Performance Liquid Chromatography (HPLC)
  • Rotary Evaporator
  • Freeze Dryer

Key Services

  • Mycotoxin testing, Blood Chemistries, Safety and Efficacy of herbal products, Sickle cell screening
Key Research Projects
The Human Heredity and Health in Africa Kidney Disease Research Network (H3A-KDRN) Genome Laboratory
Newborn Screening For Sickle Cell Disease
Biomonitoring And Control of Environmental Toxicants: Heavy Metals And Mycotoxins
Drug Interactions
Anti-COVID-19 Studies
Antimalarial Studies
Anticancer Studies
Gallery
Clinical Pathology Gallery-1
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Research Scientists
Prof. Dziedzom Komi de Souza
HOD, Associate Professor
Prof Regina Appiah-Opong
Professor
Dr. Kwabena Owusu Danquah
Research Fellow
Dr. Justice Kumi
Research Fellow
Research Staff
Abigail Aning
Principal Research Assistant
Elisha Larbi Nketia
Principal Research Assistant
Nana Yaa Achiaa Karikari Agyemang
Principal Research Assistant
Louisa Acquah
Research Assistant
Miriam Lawson Gakpey
Senior Research Assistant
Rev. Mrs. Eunice Etornam Ampem Danso
Senior Technologist
Janet Abena Ampofo
Technologist
Administrative Assistant
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Key Publications

Plant Medicine Research

Anticancer

  1. J.K. Abankwa, E. Dotse, R. Appiah-Opong, A.K. Nyarko (2020). Antioxidant and anti-prostate cancer activities of Moringa oleifera, Phyllanthus amarus and Carica papaya. Health Sciences Investigations Journal. 1(1):24-30.
  2. P. Amoateng, E.O. Bekoe, S.K. Amponsah, R. Appiah-Opong, D. Osei-safo, B.B. N’guessan, M.V.N.L. Chaitanya, R. Rajeshkumar, S.P. Dhanabal. (2020) Antioxidant and anti-proliferative effects of an ethyl acetate fraction of the hydro-ethanolic extract of Synedrella nodiflora (L) gaertn. International Journal of Pharmacy and Pharmaceutical Sciences, 12(11):136-143
  3. B.B. N’guessan, A.D. Asiamah, N.K. Arthur, S. Frimpong-Manso, P. Amoateng, S.K. Amponsah, K.E. Kukuia, J.A. Sarkodie, K.F-M. Opuni, I.K. Asiedu-Gyekye, R. Appiah-Opong. (2021) Ethanolic extract of Nymphaea lotus L. (Nymphaeaceae) leaves exhibits in vitro antioxidant, in vivo anti-inflammatory and cytotoxic activities on Jurkat and MCF-7 cancer cell lines. BMC Complementary Medicine and Therapies (2021) 21:22 doi.org/10.1186/s12906-020-03195-w

 

Antimalarial

  1. Kwansa-Bentum, K. Agyeman, J. Larbi-Akor, C. Anyigba, R. Appiah-Opong. (2019). In vitro assessment of antiplasmodial activity and cytotoxicity of Polyalthia longifolia leaf extracts on Plasmodium falciparum strain NF54. Malaria Research Treatment doi.org/10.1155/2019/6976298
  2. I. Dadzie, S.A. Avorgbedo, R. Appiah-Opong, O. Cudjoe. (2020) Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures. International Journal of Microbiology, Doi.org/10.1155/2020/8645691
  3. C.J. Ikem, R. Appiah-Opong, A.N. Oli, M.C. Ugwu, P. Amoateng, K. Agyemang, D.C. Nwobodo, C.O. Esimone. (2020). In vitro and in vivo antiplasmodial assays of selected Nigerian commercial herbal formulations. Journal of Herbmed Pharmacology, 9(4):374-381.
  4. E.K. Kumatia, F. Ayertey, R. Appiah-Opong, P. Bolah, E. Ehun, J. Dabo. (2021) Antrocaryon micraster (A. Chev. And Guillaumin) stem bark extract demonstrated anti-malaria action and normalized hematological indices in Plasmodium berghei infected mice in the Rane’s test. Journal of Ethnopharmacology, doi.org/10.1016/j.jep.2020.113427
  5. E.K. Kumatia, F. Ayertey, R Appiah-Opong, G.K. Bagyour, K.O. Asare, V.C. Mbatcho, J. Dabo. (2021). Intervention of standardized ethanol leaf extract of Annickia polycarpa, (DC.) Setten and Maas ex I.M. Turner. (Annonaceae), in Plasmodium berghei infected mice produced anti-malaria action and normalized gross hematological indices. Journal of Ethnopharmacology, doi.org/10.1016/j.jep.2020.113449
  6. J.N. Amissah, F.E. Alorvor, B.A. Okorley, C.M. Asare, D. Osei-Safo, R. Appiah-Opong, I. Addae-Mensah. (2022). Mineral fertilization influences the growth, Cryptolepine yield, and bioefficacy of Cryptolepis sanguinolenta (Lindl.) Schlt. Plants, 11:122. https:// doi.org/10.3390/plants11010122
  7. R. Appiah-Opong, K. Agyemang, E. Dotse, P. Atchoglo, K. Baffour-Awuah Owusu, A. Aning, M. Sakyiamah, R. Adegle, F. Ayertey, A. Ampomah Appiah, A. K. Nyarko. (2022). Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants. Journal of Evidence-Based Integrative Medicine, 27: 1-8. doi: 10.1177/2515690X211073709

 

Anti-leishmanial

  1. R.T. Yamthe, T.J. Philips, D. Osei-Safo, P.T. Djouonzo, O. Agyapong, E. Dotse, P.V.T. Fokou, S.K. Kwofie, F.F. Boyom, A.K. Nyarko, R. Appiah-Opong, M.D. Wilson. (2020). Antileishmanial effects of Sargassum vulgare products and prediction of trypanothione reductase inhibition by fucosterol. Future Drug Discovery, doi.org/10.4155/fdd-2020-0002
  2. K. Kowa, L.R.Y. Tchokouaha, J.N. Nyemb, H.K. Wabo, A.T. Tchinda, R. Appiah-Opong, G.A. Agbor, P. Tane, M. Frederich. (2020). Antipromastigote and cytotoxic activities of some chemical constituents of Hypericum lanceolatum Lam. (Guttifereae). Journal of Applied Pharmaceutical Science, 10(1):026-032.

 

Anti-schistosomal, anti-onchocercal and anti-trypanosomal

  1. E.B. Twumasi, P.I. Akazue, K. Kyeremeh, T.M. Gwira, J. Keiser, F. Cho-NgwaI, A. Flint, B. Anibea, E.Y. Bonsu,

R.K. Amewu, L.E. Amoah, R. Appiah-Opong, D. Osei-Safo. (2020). Anti-schistosomal, anti-onchocercal and anti-trypanosomal potentials of some Ghanaian traditional medicines and their constituents. PLOS Neglected Tropical Diseases, doi.org/10.1371/journal.pntd.0008919

 

Drug interactions

  1. K. Amponsah, B.B. N’guessan, M. Akandawen, A. Aning, S.Y. Agboli, E.A. Danso, K. F-M. Opuni, I.J. Asiedu-Gyekye, R. Appiah-Opong. (2020) Effect of Cellgevity supplement on selected rat liver cytochrome P450 enzyme activity and pharmacokinetic parameters of carbamazepine. Evidence-Based Complementary and Alternative Medicine doi.org/10.1155/2020/7956493

 

Other Publications

  1. S. Achampong, R. Appiah-Opong, A. Ocloo. (2019) Effects of Aqueous Extracts of Taraxacum officinale, Morinda citrifolia, Milletia thonningii and Noni on Mitochondrial function. Journal of Biological Sciences, 19 (6):381-390.
  2. Ayertey, E. Ofori-Attah, S. Antwi, M. Amoa-Bosompem, G. Djameh, N.L. Lartey, M. Ohashi, K.A. Kusi, A.A. Appiah, R. Appiah-Opong, L.K. Okine. (2020) Anti-inflammatory activity and mechanism of action of hydroethanolic leaf extract of Morinda lucida Benth. Journal of Traditional and Complementary Medicine, 11(3):249-258. doi.org/10.1016/j.jtcme.2020.07.001
  3. R. Appiah-Opong. (2020) The coronavirus (COVID) pandemic. Health Sciences Investigations Journal. 1(1):3-4.

 

Environmental Toxins – Mycotoxins and Heavy metals

  1. Kumi, KA.A-O. Agyei-Heneku, M. Ofosuhene. (2019) Levels of aflatoxins and fumonisins in poultry feed from Ghana. Online Journal of Animal Feed Research, 9(6):241-246.
  2. Ofori-Attah, A. Aning, M. Ofosuhene, J. Kumi, R. Appiah-Opong. (2021). Determination of aflatoxin levels in bokina beverage. Ghana Medical Journal, 55(4): 292-297. doi: http://dx.doi.org/10.4314/gmj.v55i4.10
  3. Appiah‑Opong, A. Ofori, M. Ofosuhene, E. Ofori‑Attah, F.K.E. Nunoo, I. Tuffour,· C. Gordon, D.K. Arhinful, A.K. Nyarko, B.Y. Fosu‑Mensah. (2021). Heavy metals concentration and pollution index (HPI) in drinking water along the southwest coast of Ghana. Applied Water Science, doi.org/10.1007/s13201-021-01386-5 
Internal Collaborator(s)
  • University of Ghana Department of Virology, NMIMR
  • University of Ghana epartment of Animal Experimentation, NMIMR
  • University of Ghana Department of Parasitology, NMIMR
  • University of Ghana Department of Biochemistry Cell and Molecular Biology
  • University of Ghana Department of Chemistry
  • University of Ghana Department of Pharmacology and Toxicology, School of Pharmacy
  • University of Ghana Department of Pharmacognosy, School of Pharmacy
  • University of Ghana Department of Chemical Pathology, School of Basic and Allied Health Sciences
  • University of Ghana Department of Crop Science, School of Agriculture
  • University of Ghana Department of Animal Biology and Conservation Science, School of Basic and Applied Sciences
  • Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi
  • University of Allied Health Sciences, Ho
External Collaborator(s)
  • Nagasaki International University, Japan
  • Mayo Clinic, Rochester, Minnesota, USA
Funder(s)
  • Third World Academy of Sciences (TWAS)
  • University of Ghana Research Fund
  • Lifespan/Tufts/Brown Centre for AIDS Research
  • Ministry of Education Science and Technology, Japan
  • Ghana Chamber of Mines
  • Worldwide Universities Network