Animal Experimentation
Vision Statement
To be a strategic partner with unrivalled resources and expertise in the production of Laboratory Animals and provision of standardized Animal Experimentation services as well as training of Laboratory Animal Scientists & Technicians for the Biomedical community in Africa.
Mission Statement
To provide well-defined Laboratory Animals for Research, Teaching and Testing for the improvement of human health, taking cognisance of their humane care and use and the 3Rs (Reduction, Refinement & Replacement)
Departmental Research Activities
- Establishment and characterization of Specific Pathogen Free (SPF) Animal Facilities and development of Animal Models for biomedical research
- Pre-clinical safety and efficacy profiling of medical plant extracts in well-defined laboratory animals.
- Ethical use of animals in biomedical research in Ghana
- Infectious diseases research under the One Health concept
Areas of expertise
- Laboratory Animal Breeding and husbandry
- Animal facility management and advisory services
- Microbiology and Molecular genotyping
- Veterinary care and diagnostics
- Histopathological tissue processing and pyrogen testing
Key Research Projects
Gallery
Key Publications
- Dugbartey GJ, Alornyo KK, N’guessan BB, Atule S, Mensah SD, Adjei S. Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy. https://doi.org/10.1016/j.biopha.2022.112818
- Djameh GI. Nyarko S, Tetteh-Tsifoanya M, Marfo FM, Adjei S, Blay EA., Anang AK, Ayi I. Preclinical Immuno-recognition and Neutralization of Lethality Assessment of a New Polyvalent Antivenom, VINS Snake Venom Antiserum – African IHS®, against Envenomation of Ten African Viperid and Elapid Snakes. Journal of Scientific Research & Reports 27(11): 25-43, 2021; Article no. JSRR.75395 ISSN: 2320-0227
- Appiah-Opong R, Tuffour I, Ofori-Attah E, Aning A, Atchoglo P, Danso EA, Ahedor B, Adjei S, Nyarko AK. In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines. J Evid Based Integr Med. 23:2515690X18810001. doi: 10.1177/2515690X18810001
- Amoateng P, Kukuia KKE, Mensah JA, Osei-Safo D, Adjei S, Eklemet AA, Vinyo EA, Karikari TK. An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms. Metabolic Brain Disease https://doi.org/10.1007/s11011-018-0244-0
- Amoateng P, Osei-Safo D, Kukuia KKE, Adjei S, Akure OA, Agbemelo-Tsomafo C, Adu-Poku SN, Agyeman-Badu KY. Psychotropic Effects of an Alcoholic Extract from the Leaves of Albizia zygia (Leguminosae-Mimosoideae). Evidence-Based Complementary and Alternative Medicine, Article ID 9297808, 12 pages https://doi.org/10.1155/2017/9297808
- Amoateng P, Adjei S, Osei-safo D, Kukuia KKE, Bekoe EO, Karikari TK, Kombian SB. Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis. BMC Complementary and Alternative Medicine 17:389 DOI 10.1186/s12906-017-1901-2
- Amoateng P, Adjei S, Osei-safo D, Kukuia KKE, Karikari TK, Nyarko AK. An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice. J Basic Clin Physiol Pharmacol; DOI 10.1515/jbcpp-2016-0115
- Amoateng P, Adjei S, Osei-safo D, Kukuia KKE, Kretchy IA, Sarkodie JA, N’Guessan BB. Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats. BMC Res Notes 10:226 DOI 10.1186/s13104-017-255 1-7
- Asare GA, Ngala RA, Afriyie D, Adjei S, Nyarko A, Anang-Quartey Y, Asiedu B, Doku D, Amoah BY, Bentum K, Musah I, Mossanda K. Calcium – Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug – Croton membranaceus Mu?ll.Arg. BMC Complementary and Alternative Medicine 17:152 DOI 10.1186/s12906-017-1663-x
- Azumah BK, Addo PG, Dodoo A, Awandare G, Mosi L, Boakye DA, Wilson MD. Experimental demonstration of the possible role of Acanthamoeba polyphaga in the infection and disease progression in Buruli Ulcer (BU) using ICR mice. PLoS One. 2017 Mar 22;12(3):e0172843. doi: 10.1371/journal.pone.0172843. eCollection 2017. PMID: 28329001
- Owusu E, Newman MJ, Addo KK, Addo P. In Vitro Susceptibility of Mycobacterium ulcerans Isolates to Selected Antimicrobials. Can J Infect Dis Med Microbiol. 2017; 2017:5180984. doi: 10.1155/2017/5180984. Epub 2017 Mar 14. PMID: 28392809
- Amoateng P, Adjei S, Osei-safo D, Ahedor B, Mahmood SA, N’guessan BB, Asiedu-Gyekye IJ, Nyarko AK. Long-term continuous administration of a hydro-ethanolic extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, haematological and histopathological changes. Ghana Med. J.; 50(3): 163-171
- Asiedu-Gyekye IJ, Seidu MA, N’guessan BB, Frimpong–Manso S, Sarkodie JE, Adjei S, Kutu S, Osei-Little J, Nyarko AK, Debrah P. A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity. BMC Complementary and Alternative Medicine 16:348,
- Debrah P, Nettey H, Miltersen KK, Ayeh-Kumi P, Brock B, Sarkodie JA, Akwo-Kretchy I, Owusu-Danso P, Adjei S, Petersen E, Hardlei TF. Artemether–Lumefantrine Concentrations in Tablets and Powders from Ghana Measured by a New High-Performance Liquid Chromatography Method. Am J Trop Med Hyg. 95:158-163
- Asiedu-Gyekye IJ, Kukuia KKE, Seidu AM, Antwi-Boasiako C, N’guessan BB, Frimpong-Manso S, Adjei S, Zobi J, Tettey AT, Nyarko AK. Unsweetened natural cocoa powder has the potential to attenuate high dose Artemether-Lumefantrine-Induced hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 7387286, 11 pages http://dx.doi.org/10.1155/2016/7387286
- Tsouh PV, Addo P, Yeboah-Manu D, Boyom FF. Methods used in preclinical assessment of anti-Buruli ulcer agents: A global perspective. J Pharmacol Toxicol Methods. 2015 May-Jun; 73:27-33. doi: 10.1016/j.vascn.2015.03.001. Epub 2015 Mar 16.
- Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo PG, Otchere I, Kissi-Twum A. Antimycobacterial and cytotoxic activity of selected medicinal plant extracts. J Ethnopharmacol. 2016 Apr 22; 182:10-5. doi: 10.1016/j.jep.2016.02.010. Epub 2016 Feb 11. PMID: 26875647
- Tsouh Fokou PV, Kissi-Twum AA, Yeboah-Manu D, Appiah-Opong R, Addo P, Tchokouaha Yamthe LR, Ngoutane Mfopa A, Fekam Boyom F, Nyarko AK. In Vitro Activity of Selected West African Medicinal Plants against Mycobacterium ulcerans Disease. Molecules. 2016 Apr 13;21(4):445. doi: 10.3390/molecules21040445. PMID: 27089314
- Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo PG, Otchere ID, Kissi-Twum A. In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and nonpathogenic mycobacterial strains. Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S106-S107. doi: 10.1016/j.ijmyco.2016.05.004. Epub 2016 Jul 5. PMID: 28043491
- Tsouh Fokou PV, Appiah-Opong R, Yeboah-Manu D, Kissi-Twum AA, Yamthe LR, Mokale Kognou AL, Addo P, Boyom FF, Nyarko AK. Antimycobacterial potency and cytotoxicity study of three medicinal plants. Int J Mycobacteriol. 2016 Dec;5 Suppl 1: S206-S207. doi: 10.1016/j.ijmyco.2016.10.012 Epub 2016 Oct 27. PMID: 28043557
- Tsouh Fokou PV, Kissi-Twum AA, Yeboah-Manu D, Appiah-Opong R, Addo P, Yamthe LR, Mfopa AN, Boyom FF, Nyarko AK. Antimycobacterial ingredients from plants used in traditional medicine to treat Buruli ulcer. Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S204-S205. doi: 10.1016/j.ijmyco.2016.11.025. Epub 2016 Nov 29. PMID: 28043556
- Asare GA, Adjei S, Afriyie D, Appiah-Danquah AB, Asia J, Asiedu B, Santa S, Doku D. Croton membranaceus Improves Some Biomarkers of Cardiovascular Disease and Diabetes in Genetic Animal Models. Journal of Clinical and Diagnostic Research, 9 (12), OF1 ~ OF5, (2015)
- Asare GA, Yahaya ES, Afriyie DK, Adjei S, Asiedu B. Genotoxic and Cytotoxic Activity of Aqueous Extracts of Croton membranaceus in Rodent Bone Marrow and Human Benign Prostate Hyperplasic Cells. European Journal of Medicinal Plants 9(2): 1 – 7
- Asare GA, Afriyie D, Ngala RA, Annan Y, Appiah AA, Musah X, Adjei S, Bamfo KB, Sule SD, Gyan BA, Edoh DA. Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract. Evidence-based Complementary and Alternative Medicine; DOI: 10.1155/2015/365205
- Amoateng P, Adjei S, Osei-Safo D, Ofori-Ameyaw E, Ahedor B, N’guessan BB, Nyarko AK. A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats. J Basic Clin Physiol Pharmacol 26 (4): 383 ~ 394 (2015)
- Tsouh Fokou PV, Nyarko AK, Appiah-Opong R, Tchokouaha Yamthe LR, Addo P, Asante IK, Boyom FF. Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries. J Ethnopharmacol. 2015 Aug 22; 172:297-311. doi: 10.1016/j.jep.2015.06.024. Epub 2015 Jun 20. PMID: 26099634
- Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo PG. Current perspectives in drug discovery against tuberculosis from natural products. Int J Mycobacteriol. 2015 Sep;4(3):165-83. doi: 10.1016/j.ijmyco.2015.05.004. Epub 2015 Jun 3. PMID: 27649863
- Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu D, Addo PG. Medicinal plants used to treat TB in Ghana. Int J Mycobacteriol. 2015 Jun;4(2):116-23. doi: 10.1016/j.ijmyco.2015.02.003. Epub 2015 Mar 28. PMID: 26972879
- Appiah-Opong R, Tuffour I, Ofori-Attah E, Aning A, Atchoglo P, Danso EA, Ahedor B, Adjei S, Nyarko AK. In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines. J Evid Based Integr Med. 23:2515690X18810001. doi: 10.1177/2515690X18810001
- Debrah P, Nettey H, Miltersen KK, Ayeh-Kumi P, Brock B, Sarkodie JA, Akwo-Kretchy I, Owusu-Danso P, Adjei S, Petersen E, Hardlei TF. Artemether–Lumefantrine Concentrations in Tablets and Powders from Ghana Measured by a New High-Performance Liquid Chromatography Method. Am J Trop Med Hyg. 95:158-163
Internal Collaborator(s)
- Faculty in the Department of Clinical Pathology, NMIMR
- Faculty in the Department of Immunology
- Dr. Irene Ayi (Department of Parasitology)
- UG School of Biomedical and Allied Health Sciences
- UG School of Veterinary Medicine
- Department of Animal Science, UG
- UG School of Pharmacy
- Prof. Mike Yaw Osei-Atweneboana, CSIR-Water Research Institute
External Collaborator(s)
- Hokkaido University International Institute for Zoonosis Control, Japan
- Laboratory of Animal Experimentation, Institute for Genetic Medicine, Hokkaido University, Japan
- Laboratory of Animal Genetics, Nagoya University, Japan
- College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB), Makerere University, Uganda
Funder(s)
- Japan International Coorporation Agency (JICA)
- Office of Research, Innovation and Development (ORID), University of Ghana