Insecticide Resistance
Project Lead(s)
Associate Professor
Project Background
Malaria and arboviral diseases insecticide-based vector control remains one of the major strategies being adopted for the control of malaria and arboviruses globally and in Ghana. However, insecticide resistance threatens to hinder the successful implementation of malaria vector control program in the country. There is very little information on the insecticide resistance status of malaria vectors across the various ecological zones in the country. In collaboration with the National Malaria Control Programme, I have helped to establish the National Insecticide Resistance Monitoring Partnership (NIRMOP) concept for the Ghana Health Service and the National Malaria Control Programme and currently coordinating the collection of resistance data from 20 sentinel sites across the country. We are also generating insecticide resistance data on Aedes mosquitoes in Ghana.
Objectives/Research Areas
- Malaria and Arboviral Entomology: Research interest is in the determination of transmission indices for vector-borne diseases, monitoring vector control interventions, insecticide resistance, vector species identification, vector control, and effectiveness of insecticide treated nets.
- Phase III trial of the efficacy and durability of long-lasting nets
- Impact of different Vector control interventions on vector-borne diseases
Key Findings
We have provided consultancy services to many vector control companies in Ghana with regard to insecticide resistance management. I was also involved in monitoring the insecticide profile of malaria vectors in the Kome area of Chad. I was a consultant for WHO that formulated the National Insecticide Resistance Monitoring and Management Plan for Ghana. The information from this research has helped the NMCP in Ghana to make evidence-based decisions on malaria vector control and also the management of insecticide resistance in the country.
Ongoing Activities
- Malaria and Arboviral Entomology: Research interest is in the determination of transmission indices for vector borne diseases, monitoring vector control interventions, insecticide resistance, vector species identification, vector control and effectiveness of insecticide treatment nets.
- Phase III trial of the efficacy and durability of long-lasting nets
- Impact of different Vector control interventions on vector-borne diseases
Key Publications
- Samuel Dadzie, Maxwell A Appawu, Clement Kerah-Hinzoumbe, Martin C Akogbeto, Michele Adimazoya, Demba Kodindo Israel, Amen Nakebang Fadel, Jacob Williams 2016 Species composition and insecticide resistance status of Anopheles gambiae s.l (Culicidae) in Kome, Southern Chad and the implications for malaria control, Parasit Vectors, 9 (1):465
- Hitoshi Kawada, Yukiko Higa, Kyoko Futami , Yuto Muranami, Emiko Kawashima, Joseph HN Osei, Kojo Yirenkyi Sakyi, Samuel Dadzie, Dziedzom K. de Souza, Maxwell Appawu, Nobuo Ohta, Takashi Suzuki, Noboru Minakawa 2016 Discovery of Point Mutations in the Voltage-Gated Sodium Channel from African Aedes aegypti Populations: Potential Phylogenetic Reasons for Gene Introgression, Plos Negl Trop Dis, 10 (6):e0004780
- Joseph Chabi, Philip Kweku Baidoo, Alex Kojo Datsomor, Dora Okyere, Aikins Ablorde, Alidu Iddrisu, Michael David Wilson, Samuel Kweku Dadzie, Helen Pates Jamet, Joseph Diclaro II, 2016 Insecticide susceptibility of natural populations of Anopheles coluzzii and Anopheles gambiaes. from Okyereko irrigation site, Ghana, West Africa, Parasites & Vectors, 9:162-170
- Mitchell S. N., Rigden D. J., Dowd A.J., Lu F., Wilding C.S., Weetman D., Dadzie S., Jenkins A. M., Regna K., Boko P; Djogbenou L., Muskavitch M. A., Ranson H., Paine M J., Mayans O., Donnelly M. J., 2014. Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae. PloS one.;9(3):e92662
- Insecticide susceptibility of gambiae s.l. across 20 sentinel sites in Ghana, Report submitted to the Ghana Health Service/National Malaria Control Programme, 2015.
- Guidelines for National Insecticide Resistance Monitoring and Management Plan for Ghana 2017-2023
- Grau-Bové X, Lucas E, Pipini D, Rippon E, van ‘t Hof AE, Constant E, Dimitra P, Emily R, Samuel D, Alexander Egyir-Yawson, John Essandoh, Joseph Chabi, Luc Djogbénou, Nicholas J Harding, Alistair Miles, Dominic Kwiatkowski, Martin J Donnelly, David Weetman 2021 Resistance to pirimiphos-methyl in West African Anophelesis spreading via duplication and introgression of the Ace1 PLoS Genet 17(1): e1009253. https://doi.org/10.1371/journal.pgen.1009253
Team
Internal Collaborator(s)
Department of Virology
Department of Epidemiology
Department of Bacteriology
External Collaborator(s)
Ghana Health Service
World Health Organization
Centers for Disease Control and Prevention
USAID
Navy Entomology Center of Excellence
NAMRU-3 Unit
Funder(s)
BANGA-Africa Project. PI Aedes Mosquito Surveillance for Prediction and Control of Arboviral Disease Outbreak: A pilot Study of the Accra Metropolis. (2019- 2022)
Global Health Engagement Research Initiative (GHERI). PI. Development of an Expeditionary Operational Entomology Research Capability in Strengthening Ghana’s National Malaria Control Program and Support Building Other Africa Malaria Task Force Partner Nation Malaria Control Capacity. (August 2019-July 2022)
CCMD GHE. PI. Navrongo Integrated Vector Surveillance Project (NISP). (2019-2024).